品名：3-異丁基-1-甲基黃嘌呤

貨號(hào)：I5879

別名: 1-甲基-3-異丁基黃嘌呤, 3,7-二氫-1-甲基-3-（2-甲基丙基）-1H-嘌呤-2,6-二酮, 3-異丁基-1-甲基-2,6（1H,3H）-嘌呤二酮, IBMX

• CAS號(hào): 28822-58-4

• 經(jīng)驗(yàn)分子式（希爾表示法）: C₁₀H₁₄N₄O₂

• 分子量: 222.24

• Beilstein Registry Number: 247859

• 酶學(xué)委員會(huì)編號(hào): 249-259-3

產(chǎn)品描述：

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包裝

1, 5 g in poly btl

100 mg in poly btl

250 mg in poly tube

Biochem/physiol Actions

Non-specific inhibitor of cAMP and cGMP phosphodiesterases. The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa （IC₅₀: 1.3 μM）. Also serves as an adenosine receptor antagonist. Shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Induces calcium release from intracellular stores in sensory neurons.¹

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